Christ Church was founded in 1546 by King Henry VIII, the college is uniquely a joint foundation of the university and the cathedral of the Oxford diocese, Christ Church Cathedral, which also serves as the college chapel and whose dean is ex officio the college head.

As of 2022, Christ Church had the largest financial endowment of any Oxford college at £770 million. From 2022, the college had 661 students. Its grounds contain a number of architecturally significant buildings including Tom Tower (designed by Sir Christopher Wren), Tom Quad (the largest quadrangle in Oxford), and the Great Dining Hall, which was the seat of the parliament assembled by King Charles I during the English Civil War. The buildings have inspired replicas throughout the world in addition to being featured in films such as Harry Potter and The Golden Compass, helping Christ Church become the most popular Oxford college for tourists with almost half a million visitors annually.

In 1525, at the height of his power, Thomas Wolsey, Lord Chancellor of England and Cardinal Archbishop of York, suppressed St Frideswide's Priory in Oxford and founded Cardinal College on its lands, using funds from the dissolution of Wallingford Priory and other minor priories. He planned the establishment on a magnificent scale, but fell from grace in 1529, with the buildings only three-quarters complete, as they were to remain for 140 years.

In 1531 the college was itself suppressed, but it was refounded in 1532 as King Henry VIII's College by Henry VIII, to whom Wolsey's property had escheated. Then in 1546 the King, who had broken from the Church of Rome and acquired great wealth through the dissolution of the monasteries in England, refounded the college as Christ Church as part of the reorganisation of the Church of England, making the partially demolished priory church the cathedral of the recently created Diocese of Oxford.

Major additions have been made to the buildings through the centuries, and Wolsey's Great Quadrangle was crowned with the famous gate-tower designed by Christopher Wren. To this day, the bell in the tower, Great Tom, is rung 101 times at 9 pm measured by Oxford time, meaning at 9:05 pm GMT/BST every night, once for each of the 100 original scholars of the college, plus one more stroke added in 1664. In former times this was done at midnight, signalling the close of all college gates throughout Oxford. Since it took 20 minutes to ring the 101, the Christ Church gates, unlike those of other colleges, did not close until 12:20 am. When the ringing was moved back to 9:00 pm, Christ Church gates still remained open until 12.20, 20 minutes later than any other college. Although the clock itself now shows GMT/BST, Christ Church still follows Oxford time in the timings of services in the cathedral.

King Charles I made the Deanery his palace and held his Parliament in the Great Hall during the English Civil War. 

For over four centuries Christ Church admitted men only; the first female students at Christ Church matriculated in 1980.

Christ Church, Oxford - Wikipedia